What is DCK?

2′-Oxo-PCM (also known as deschloroketamine, O-PCM, DXE, and DCK) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic and hallucinogenic effects when administered. Other chemicals in this class include DMXE, 2-FDCK and 3-Me-PCPy.

DCK was one of the first ketamine analogues that appeared on the research chemical scene in the early 2010s. Many researchers experiment with it as a legal alternative to ketamine. However, the results achieved are substantially different. Notably, the duration of experiments with DCK tends to last several hours, compared to 30-60 minutes with ketamine or 2-FDCK.

Chemical Properties

Deschloroketamine, or 2-Phenyl-2-(methylamino)cyclohexanone, is classed as an arylcyclohexylamine drug. Arylcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Descholoroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone). An amino methyl chain (-N-CH3) is bound to the adjacent alpha carbon (R2) of the cyclohexanone ring.

Descholoroketamine is a chiral molecule and is often produced as a racemate. Des- is a prefix used in chemistry to denote the absence of a functional group (in this case “chloro”) hence deschloroketamine is named for lacking a chlorine substitution on its phenyl ring, which is found in ketamine.

Pharmacological effects

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-MeO-PCP, PCP and MXE. With this in mind, DCK is thought to act as an NMDA receptor antagonist. NMDA receptors, a type of glutamate receptor, allow for excitatory electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives inactivate the NMDA receptors by blocking them. This disconnection of neurons leads to the general loss of bodily sensation, motor coordination, memory recall and eventually this substance’s equivalent of the “k-hole.”

Some of the most commonly reported effects are:

• Spontaneous physical sensations
• Motor control loss
• Depersonalization
• Dream potentiation
• Creativity enhancement

Potential Side Effects

• Nausea
• Sedation
• Decreased libido
• Time distortion
• Optical sliding

This list is not exhaustive, so do your own research into the legal status in your country before ordering!